Immunology and Inflammation Research 条件を付加する。利用者は事前に寄託者の提供承諾書を得る。<br>研究成果の公表にあたって寄託者の指定する文献を引用する。<br>研究成果の公表にあたって謝辞の表明を必要とする。<br>Inquiries regarding the use of the BIOLOGICAL RESOURCE for commercial purposes including research use by for-profit companies should be directed to: <br>Dr. Par Olsson<br>Director, Intellectual Property<br>Ludwig Institute for Cancer Research<br>666 Third Avenue<br>New York, NY 10017<br>Tel. +1-212-450-1500<br>Fax. +1-212-450-1535<br><br>Ownership of modifications and derivatives including crossed progeny of the BIOLOGICAL RESOURCE will be determined in accordance with applicable law governing inventorship and the creative input of the parties and the Recipient agrees to report any such progeny to LICR. The RIKEN BRC, the LICR and Recipient agree that no party will license or otherwise commercialize any such invention in the absence of an agreement to be negotiated in good faith by the parties hereto, providing for, inter alia, the sharing of royalty income. The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. Inquiries regarding the use of the BIOLOGICAL RESOURCE for commercial purposes including research use by for-profit companies should be directed to: <br>Dr. Par Olsson<br>Director, Intellectual Property<br>Ludwig Institute for Cancer Research<br>666 Third Avenue<br>New York, NY 10017<br>Tel. +1-212-450-1500<br>Fax. +1-212-450-1535<br><br>Ownership of modifications and derivatives including crossed progeny of the BIOLOGICAL RESOURCE will be determined in accordance with applicable law governing inventorship and the creative input of the parties and the Recipient agrees to report any such progeny to LICR. The RIKEN BRC, the LICR and Recipient agree that no party will license or otherwise commercialize any such invention in the absence of an agreement to be negotiated in good faith by the parties hereto, providing for, inter alia, the sharing of royalty income. W9.5 [129S1/Sv-Oca2<+> Tyr<+> Kitl<+>] ホモ同士の交配にて継代が可能。 Necessary documents for ordering:<ol><li>Approval form (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_6.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_d.docx">English</A>)</li><li>Order form (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx">English</A>)</li><li>Category I MTA: MTA for distribution with RIKEN BRC (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx">English</A>)</li><li>Acceptance of responsibility for living modified organism (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_7.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_g.docx">English</A>)</li></ol> TNF.K.O Homozygote x HomozygoteHomozygous mutant mice show a normal development and no gross morphological abnormalities. Ludwig Institute for Cancer Research Ludwig Institute for Cancer Research B6.129S1-Tnf<tm1Ljo>/Rbrc. TNF, tumor necrosis factor is a multifunction proinflammatory cytokine, play a critical role in regulating of the development and function of the immune system. Homozygous mutant mice show no cytotoxicity of TNF. B6.129S1-Tnf<tm1Ljo>/Rbrc Developed by Drs. Michael W Marion and Lloyd J. Old, Ludwig Institute for Cancer Research in 1999. Neomycin cassettes were inserted into the nucleotides 3704-5364 of the Tnf gene. C（3〜6か月） Gerd Ritter Gerd Ritter RBRC00306 Developmental Biology Research (1)　TNFノックアウトマウスは健康に発育し、子孫を繁殖させる。(2)　TNFの生体に及ぼす影響をin vivoにて検討できる。 covid19_onset TNF.K.O TNF.K.O <a href='https://brc.riken.jp/mus/pcr00306'>Genotyping protocol -PCR-</a> 1996年、Dr. Michael W.Marino、Ludwig Institute for Cancer Research (1)　TNFノックアウトマウスは健康に発育し、子孫を繁殖させる。,(2)　TNFの生体に及ぼす影響をin vivoにて検討できる。 true Homozygote x Homozygote Homozygous mutant mice show a normal development and no gross morphological abnormalities. C (3-6 months) mouse tumor necrosis factor genomic DNA, E. coli neo, mouse phosphoglycerate kinase promoter (PGK promoter)